Amend Your Inheritance
Passed down from generation to generation, cancer is a form of inheritance most families don’t like to talk about. However, if cancer runs in your family, it’s better to find out sooner rather than later. Knowing your lifetime cancer risk is the first step to beating the disease. Abandon the cure-driven approach and move toward proactive prevention.
Take Control of Cancer
Most cancers can be linked to a genetic component. For example, women with BRCA1 and BRCA2 genetic mutations are up to 76 percent more likely to develop breast and ovarian cancers, compared to an average lifetime risk of 12.3 percent for the general population. Vantari testing can reveal inherited mutations that indicate increased risk for 91 types of cancer. Learning about your cancer risks can empower you to prevent cancer before it begins.
Create Your Future
Knowing your risk for cancer can motivate you to live a healthier life. If you’re genetically predisposed to certain cancers, you can choose to undergo diagnostic testing earlier in life or opt for risk-reducing surgery. You may also be motivated to make healthy changes to your diet and lifestyle. Testing for hereditary cancer risk can steer your future toward the long life you imagine.
Common Reasons for Testing
Vantari testing can help evaluate a genetic predisposition for cancer. Testing may be right for you if:
Family HistoryDo you have a family history of cancer? Having several first-degree relatives with cancer or family members who had cancer at a younger age than normal may suggest a link to a gene mutation.
Personal HistoryDo you have a personal history of cancer? Being diagnosed with one cancer puts you at increased risk for other types and further diagnostic tests may be recommended.
Breast or Ovarian CancerInherited mutations in BRCA1 or BRCA2 indicate a greatly increased risk for cancer. Proactive steps can decrease your risk and inform other family members about their risks.
Missing InformationIf you’re adopted or have gaps in your family history, hereditary cancer testing can provide information about cancers you may be predisposed to or may risk passing on to your children.
Testing for over 90 Types of Cancers
Vantari has developed a screening panel that detects 144 genetic mutations that correspond to 91 types of cancer. Well-known forms of cancers include brain tumors; melanoma; and breast, ovarian, prostate, pancreatic and Lynch cancers.
|Cowden Syndrome||AKT1, PIK3CA, PTEN|
|Fanconi Anemia||BRCA2, BRIP1, FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, PALB2, SLX4 (BTBD12)|
|Hereditary Desmoid Disease||APC|
|Li-Fraumeni Syndrome||CHEK2 (RAD53), TP53|
|Lynch Syndrome||EPCAM, MLH1, MSH2, MSH6, PMS2|
|Mismatch Repair Cancer Syndrome||MLH1, MSH2, MSH6, PMS2|
|Mosaic Variegated Aneuploidy||BUB1B|
|Seckel Syndrome 1||ATR|
|von Hippel-Lindau Syndrome||VHL|
|Hereditary Adrenal Pheochromocytoma||MAX, TMEM127, VHL|
|Hereditary Primary Pigmented Nodular Adrenocortical Disease||PDE11A, PRKAR1A|
|Hereditary Adrenocortical Cancer||TP53|
|Hereditary Adrenal Hyperplasia||CYP21A2|
|Hereditary Isolated Pituitary Adenoma||AIP|
|Hereditary Thyroid Cancer||NDUFA13, NTRK1, RET|
|Hyperparathyroidism-Jaw Tumor Syndrome||CDC73|
|Multiple Endocrine Neoplasia||CDKN1B (p27KIP1), MEN1|
|Hereditary Bone Dysplasia with Malignant Fibrous Histiocytoma||MTAP|
|Multiple Exostoses||EXT1, EXT2|
Breast & Ovarian Cancers
|Hereditary Breast-Ovarian Cancer||BARD1, BRCA1, BRCA2, CHEK2 (RAD53), RAD51B (RAD51L1), RAD51C, RAD51D (RAD51L3)|
|Hereditary Adenomatous Polyposis||APC, MUTYH|
|Hereditary Colorectal Cancer||GALNT12, MLH3|
|Oligodontia-Colorectal Cancer Syndrome||AXIN2|
|POLD1 & POLE Associated Colorectal Adenomas||POLD1, POLE|
GI Tract Cancers
|Hereditary Barrett Esophagus/Esophageal Adenocarcinoma||ASCC1, MSR1|
|Hereditary Gastric Carcinoma||CDH1|
|Hereditary GIST||KIT (CD117), PDGFRA, SDHC|
|Juvenile Polyposis Syndrome||BMPR1A (ALK3), SMAD4|
|Peutz-Jeghers Syndrome||STK11 (LKB1)|
Head & Neck Cancers
|Dyskeratosis Congenita||DKC1, RTEL1, TERT, TINF2|
|Tuberous Sclerosis||TSC1, TSC2|
|Ataxia Telangetasia-like Disorder||MRE11A|
|Familial Monocytic Leukemia||GATA2|
|Hereditary Acute Myeloid Leukemia||CEBPA, RUNX1 (AML1)|
|Hereditary Hodgkin Lymphoma||KLHDC8B|
|Nijmegen Breakage Syndrome||NBN (NBS1)|
|Nijmegen Breakage-like Syndrome||RAD50|
|TERT Mutation-Associated Haematological Disorders||TERT|
|Hereditary Leiomyomatosis & Renal Cell Cancer||FH|
|Hereditary Melanoma & Renal Cancer||MET, MITF|
|Hereditary Wilms' Tumor||POU6F2, WT1|
|Porphyria Cutanea Tarda||UROD|
Nervous System Cancers
|Carney-Stratakis Syndrome||PRKAR1A, SDHAF2, SDHB, SDHD|
|Hereditary Neuroblastoma||ALK, KIF1B, PHOX2B|
|Rhabdoid Predisposition Syndrome||SMARCA4, SMARCB1|
|Basal Cell Nevus Syndrome||PTCH1, PTCH2|
|Familial Multiple Glomus Tumors||GLMN|
|Familial Multiple Trichoepithelioma||CYLD|
|Familial Uveal Melanoma||BAP1|
|Ferguson-Smith Syndrome||TGFBR1 (ALK5)|
|Hereditary Epidermodysplasia Verruciformis||TMC6, TMC8|
|Hereditary Leiomyomatosis & Renal Cell Cancer||FH|
|Hereditary Malignant Melanoma||CDK4, CDKN2A (p16INK4), MC1R, MITF, XRCC3|
|Palmoplantar Keratoderma & Squamous Cell Carcinoma||RSPO1|
|Xeroderma Pigmentosum||DDB2, ERCC2 (XPD), ERCC3 (XPB), ERCC4, ERCC5, ERCC6, POLH, XPA, XPC|
Soft Tissue Cancers
|Hereditary Infantile Hemangioma||ANTXR1, KDR (VEGFR3)|
|Juvenile Hyaline Fibromatosis||ANTXR2|
|Opitz Trigonocephaly Syndrome||CD96|
|SC Phocomelia Syndrome||ESCO2|
|Familial Pancreatic Cancer||BRCA2, PALB2, PALLD|
|Hereditary Pleuropulmonary Blastoma||DICER1|
|Hereditary Prostate Cancer||BRCA2, EHBP1, EPHB2, MSMB, MSR1, RNASEL|
How Testing Works
1 – Evaluate Family History
Does cancer run in your family? Mapping out your family pedigree brings your family medical history to life. Complete a family history questionnaire to determine your risk for hereditary cancers.
2 – Begin the Process
Like any diagnostic test, hereditary cancer testing must be authorized by a doctor.
3 – Collect DNA Sample
The hereditary cancer test is performed with a simple, painless saliva sample. The sample is then sent to the lab for testing.
4 – Analyze Results
Our federally-certified lab analyzes your DNA for germline mutations contributing to both common and rare familial cancers. Results are typically sent to your doctor within five to seven business days.
5 – Plan & Prepare
If your test results indicate a genetic mutation that increases your risk for cancer, you’re encouraged to meet with a genetic counselor. Early planning and preparation are key to positive health outcomes.
Testing and Insurance
Medically necessary genetic testing is commonly covered by Medicare and most major insurers. Further questions? Please contact a customer service specialist at 1.844.VANTARI or 1.844.826.8274
We're Here for You
If testing reveals you may be genetically predisposed to cancer, you’re not alone. Vantari has partnered with board-certified genetic counselors to ensure seamless answers to patient questions. Knowing your risk can help you make informed decisions, lifestyle changes or elect for risk-reducing surgery. Counselors can help you evaluate results and next steps.
Questions? We have answers.
Talk to Us
Please contact a customer service specialist at 1.844.VANTARI or 1.844.826.8274.