Vantari Genetics

Change the Course of Cancer

Amend Your Inheritance

Passed down from generation to generation, cancer is a form of inheritance most families don’t like to talk about. However, if cancer runs in your family, it’s better to find out sooner rather than later. Knowing your lifetime cancer risk is the first step to beating the disease. Abandon the cure-driven approach and move toward proactive prevention.

Take Control of Cancer

Most cancers can be linked to a genetic component. For example, women with BRCA1 and BRCA2 genetic mutations are up to 76 percent more likely to develop breast and ovarian cancers, compared to an average lifetime risk of 12.3 percent for the general population. Vantari testing can reveal inherited mutations that indicate increased risk for 91 types of cancer. Learning about your cancer risks can empower you to prevent cancer before it begins.

Create Your Future

Knowing your risk for cancer can motivate you to live a healthier life. If you’re genetically predisposed to certain cancers, you can choose to undergo diagnostic testing earlier in life or opt for risk-reducing surgery. You may also be motivated to make healthy changes to your diet and lifestyle. Testing for hereditary cancer risk can steer your future toward the long life you imagine.

Common Reasons for Testing

Vantari testing can help evaluate a genetic predisposition for cancer. Testing may be right for you if:

  • Family History
    Do you have a family history of cancer? Having several first-degree relatives with cancer or family members who had cancer at a younger age than normal may suggest a link to a gene mutation.
  • Personal History
    Do you have a personal history of cancer? Being diagnosed with one cancer puts you at increased risk for other types and further diagnostic tests may be recommended.
  • Breast or Ovarian Cancer
    Inherited mutations in BRCA1 or BRCA2 indicate a greatly increased risk for cancer. Proactive steps can decrease your risk and inform other family members about their risks.
  • Missing Information
    If you’re adopted or have gaps in your family history, hereditary cancer testing can provide information about cancers you may be predisposed to or may risk passing on to your children.
cancer_detail

Testing for over 90 Types of Cancers

Vantari has developed a screening panel that detects 144 genetic mutations that correspond to 91 types of cancer. Well-known forms of cancers include brain tumors; melanoma; and breast, ovarian, prostate, pancreatic and Lynch cancers.

General Cancers

Cancer Mutation
Bloom SyndromeBLM
Carney ComplexPRKAR1A
Costello SyndromeHRAS
Cowden SyndromeAKT1, PIK3CA, PTEN
Fanconi AnemiaBRCA2, BRIP1, FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, PALB2, SLX4 (BTBD12)
Hereditary Desmoid DiseaseAPC
Li-Fraumeni SyndromeCHEK2 (RAD53), TP53
LIG4 SyndromeLIG4
Lynch SyndromeEPCAM, MLH1, MSH2, MSH6, PMS2
Mismatch Repair Cancer SyndromeMLH1, MSH2, MSH6, PMS2
Mosaic Variegated AneuploidyBUB1B
Seckel Syndrome 1ATR
von Hippel-Lindau SyndromeVHL

Endocrine Cancers

Cancer Mutation
Hereditary Adrenal PheochromocytomaMAX, TMEM127, VHL
Hereditary Primary Pigmented Nodular Adrenocortical DiseasePDE11A, PRKAR1A
Hereditary Adrenocortical CancerTP53
Hereditary Adrenal HyperplasiaCYP21A2
Hereditary Isolated Pituitary AdenomaAIP
Hereditary Thyroid CancerNDUFA13, NTRK1, RET
Hyperparathyroidism-Jaw Tumor SyndromeCDC73
Multiple Endocrine NeoplasiaCDKN1B (p27KIP1), MEN1
Pallister-Hall SyndromeGLI3

Bone Cancers

CancerMutation
Familial OsteosarcomaTP53 
Hereditary Bone Dysplasia with Malignant Fibrous HistiocytomaMTAP
Multiple ExostosesEXT1, EXT2
Rothmund-Thompson SyndromeRECQL4

Breast & Ovarian Cancers

CancerMutation
Hereditary Breast-Ovarian CancerBARD1, BRCA1, BRCA2, CHEK2 (RAD53), RAD51B (RAD51L1), RAD51C, RAD51D (RAD51L3)

Colorectal Cancers

Cancer Mutation
Hereditary Adenomatous PolyposisAPC, MUTYH
Hereditary Colorectal CancerGALNT12, MLH3
Oligodontia-Colorectal Cancer SyndromeAXIN2
POLD1 & POLE Associated Colorectal AdenomasPOLD1, POLE

GI Tract Cancers

Cancer Mutation
Bannayan-Riley-Ruvalcaba SyndromePTEN
Hereditary Barrett Esophagus/Esophageal AdenocarcinomaASCC1, MSR1
Hereditary Gastric CarcinomaCDH1
Hereditary GISTKIT (CD117), PDGFRA, SDHC
Howel-Evans syndromeRHBDF2
Juvenile Polyposis SyndromeBMPR1A (ALK3), SMAD4
Peutz-Jeghers SyndromeSTK11 (LKB1)

Head & Neck Cancers

Cancer Mutation
Dyskeratosis CongenitaDKC1, RTEL1, TERT, TINF2
Hereditary CylindromatosisCYLD
Tuberous SclerosisTSC1, TSC2

Hematopoietic Cancers

Cancer Mutation
Ataxia TelangetasiaATM
Ataxia Telangetasia-like DisorderMRE11A
Chediak-Higashi SyndromeLYST
Familial Monocytic LeukemiaGATA2
Hereditary Acute Myeloid LeukemiaCEBPA, RUNX1 (AML1)
Hereditary Hodgkin LymphomaKLHDC8B
Nijmegen Breakage SyndromeNBN (NBS1)
Nijmegen Breakage-like SyndromeRAD50
Schwachman-Diamond SyndromeSBDS
TERT Mutation-Associated Haematological DisordersTERT
Wiskott-Aldrich SyndromeWAS

Kidney Cancers

Cancer Mutation
Birt-Hogg-Dube SyndromeFLCN
Denys-Drash SyndromeWT1
Hereditary Leiomyomatosis & Renal Cell CancerFH
Hereditary Melanoma & Renal CancerMET, MITF
Hereditary Wilms' TumorPOU6F2, WT1
Perlman SyndromeDIS3L2

Liver Cancers

Cancer Mutation
HemochromatosisHFE
Porphyria Cutanea TardaUROD
TyrosinemiaFAH

Nervous System Cancers

Cancer Mutation
Carney-Stratakis SyndromePRKAR1A, SDHAF2, SDHB, SDHD
Hereditary MedulloblastomaSUFU
Hereditary NeuroblastomaALK, KIF1B, PHOX2B
Hereditary ParagangliomasSDHA
NeurofibromatosisNF1, NF2
RetinoblastomaRB1
Rhabdoid Predisposition SyndromeSMARCA4, SMARCB1
SchwannomatosisSMARCB1
Simpson-Golabi-Behmel SyndromeGPC3

Skin Cancers

Cancer Mutation
Basal Cell Nevus SyndromePTCH1, PTCH2
Birt-Hogg-Dube SyndromeFLCN
Familial Multiple Glomus TumorsGLMN
Familial Multiple TrichoepitheliomaCYLD
Familial Uveal MelanomaBAP1
Ferguson-Smith SyndromeTGFBR1 (ALK5)
Hereditary Epidermodysplasia VerruciformisTMC6, TMC8
Hereditary Leiomyomatosis & Renal Cell CancerFH
Hereditary Malignant MelanomaCDK4, CDKN2A (p16INK4), MC1R, MITF, XRCC3
Muir-Torre SyndromeMSH2
Palmoplantar Keratoderma & Squamous Cell CarcinomaRSPO1
Xeroderma PigmentosumDDB2, ERCC2 (XPD), ERCC3 (XPB), ERCC4, ERCC5, ERCC6, POLH, XPA, XPC

Soft Tissue Cancers

Cancer Mutation
Hereditary Infantile HemangiomaANTXR1, KDR (VEGFR3)
Juvenile Hyaline FibromatosisANTXR2
Opitz Trigonocephaly SyndromeCD96
Proteus SyndromePTEN
SC Phocomelia SyndromeESCO2
Werner SyndromeWRN

Other Cancers

Cancer Mutation
Familial Pancreatic CancerBRCA2, PALB2, PALLD
Hereditary Pleuropulmonary BlastomaDICER1
Hereditary Prostate CancerBRCA2, EHBP1, EPHB2, MSMB, MSR1, RNASEL
HypoxiaCHEK1

How Testing Works

1 – Evaluate Family History

Does cancer run in your family? Mapping out your family pedigree brings your family medical history to life. Complete a family history questionnaire to determine your risk for hereditary cancers.

2 – Begin the Process

Like any diagnostic test, hereditary cancer testing must be authorized by a doctor.

3 – Collect DNA Sample

The hereditary cancer test is performed with a simple, painless saliva sample. The sample is then sent to the lab for testing.

4 – Analyze Results

Our federally-certified lab analyzes your DNA for germline mutations contributing to both common and rare familial cancers. Results are typically sent to your doctor within five to seven business days.

5 – Plan & Prepare

If your test results indicate a genetic mutation that increases your risk for cancer, you’re encouraged to meet with a genetic counselor. Early planning and preparation are key to positive health outcomes.

Testing and Insurance

Medically necessary genetic testing is commonly covered by Medicare and most major insurers. Further questions? Please contact a customer service specialist at 1.844.VANTARI or 1.844.826.8274

We're Here for You

If testing reveals you may be genetically predisposed to cancer, you’re not alone. Vantari has partnered with board-certified genetic counselors to ensure seamless answers to patient questions. Knowing your risk can help you make informed decisions, lifestyle changes or elect for risk-reducing surgery. Counselors can help you evaluate results and next steps.

Questions? We have answers.

Talk to Us

Please contact a customer service specialist at 1.844.VANTARI or 1.844.826.8274.